Black Box

In any one year, the Lush Prize may present a Black Box Prize of the full £250,000 Lush Prize fund for a key breakthrough.

The criteria for awarding a Black Box Prize are focused on projects most likely to lead to practical non-animal tests which could be accepted by regulators.

We think the most promising approaches include adverse outcome pathways, organs on chips, and computational toxicology.

Specifically the Black Box Prize is looking to award either:

  • the first, fully accepted, human relevant adverse outcome pathway for systemic toxicology or developmental toxicology OR
  • the first regulatory acceptance of a new substance using entirely non-animal methods.


We are not requesting entries or nominations for the Black Box, as any award is at the discretion of the Lush Prize organisers and Judges.

We do however welcome your suggestions or ideas.